In the Pitt Lab, we seek to understand how patterns of somatic mutations arise within the DNA of cells. The ongoing accumulation of mutations – known as genome instability (GI) – represent a history of aberrant DNA damage and repair processes within malignancies. We combine large-scale sequencing datasets, artificial intelligence, and data-intensive computing to define and biologically characterize multimodal GI patterns. This enables us to decipher how mutational processes fuel cancer evolution and can be exploited therapeutically.

Please see our Research Highlights and Publications for further details.